Epigenetics

This guide provides an introduction to performing targeted nanopore sequencing.

This guide introduces how to sequence human genomes with Oxford Nanopore, from the construction of new, highly complete reference assemblies to the comprehensive identification of variants.

This guide provides an introduction to the direct sequencing of DNA methylation in human genomes.

This end-to-end workflow provides a simple method to characterise RNA modifications from a human blood research sample using direct RNA sequencing.

This end-to-end workflow overview provides a simple solution for detecting a wide range of tumour-specific variation in a single sequencing assay.

This end-to-end workflow introduces how to perform rapid whole-genome human variant and methylation calling from a blood research sample using high-output DNA sequencing on PromethION 24.

This end-to-end workflow introduces how to generate a high-quality plant genome assembly from a leaf sample.

This end-to-end workflow provides a scalable solution for genome-wide analysis of genomic and epigenomic variants across a large cohort of human research samples with Oxford Nanopore sequencing.

Find out how multiomic nanopore sequencing can accelerate your disease research using a single platform.

In this flyer, find out how Oxford Nanopore sequencing uncovers the complete methylome and provides highly accurate and comprehensive base modification data for analysis.

Discover how the Oxford Nanopore rapid whole-genome sequencing workflow is delivering fast, actionable results in 24 hours from sample collection.

Discover EPI2ME and how it provides data analysis for all levels of expertise

In this application note, we present the design and performance of the Oxford Nanopore Hereditary Cancer Panel targeting 258 key genes implicated in cancer predisposition.

Discover how nanopore sequencing uniquely captures full-length transcripts for isoform-level transcriptome characterisation.

In this case study, discover how Kimberley Billingsley and her colleagues at the National Institutes of Health are using Oxford Nanopore large-cohort cDNA sequencing to research the human brain transcriptome, enhancing understanding of the drivers of neurodegenerative diseases.

In this masterclass, find the right human whole-genome sequencing workflow to meet your experimental goals. We’ll cover whole-genome analysis in just 24 hours through to scaling sequencing for large cohort research. In this masterclass, discover: • How Oxford Nanopore sequencing is advancing human g

In this beginner-friendly masterclass, discover how to analyse your Oxford Nanopore sequencing data. Find out how basecalling works, the common file formats you’ll encounter, and how to use MinKNOW to set up and monitor your sequencing run. Then, discover how to analyse your data with EPI2ME — no pr

Whether you’re sequencing DNA, RNA, or cDNA, a single sample or many in multiplex, there’s an Oxford Nanopore library prep kit for you. In this masterclass, discover how to choose the right one for your workflow. In this masterclass, discover: • The range of Oxford Nanopore library prep solutions av

This protocol describes how to carry out preparation and sequencing of a human cfDNA sample using the Ligation Sequencing Kit V14 (SQK-LSK114). Typically, we obtain ~50 Gb of aligned data (15x coverage) for human cfDNA samples processed with this protocol.

This protocol describes how to carry out preparation and sequencing of 12 human cell-free DNA (cfDNA) samples using the Native Barcoding Kit 24 V14 (SQK-NBD114.24). Typically, we obtain ~3 Gb of aligned data (1x coverage) for each of the 12 human cfDNA samples processed with this protocol.

For Research Use Only. Document version: RRMS_9180_v114_revM_19Sep2025

仅供研究使用。

Find out how Oxford Nanopore sequencing reveals genetic and epigenetic variation to characterise FSHD.

Presented at AACR 2026, this recording demonstrates how rapid molecular insights can be leveraged to inform clinical decision-making and advance time-critical cancer care.

In this webinar, our expert speakers will show how large-scale cancer genome—across nine African countries—is uncovering population-specific variation and epigenetic signals, that could influence biomarker discovery, drug development, and the future of inclusive precision cancer care.

Publication: Comparison of nanopore sequencing, Methylation EPIC array, and EM-Seq for DNA methylation detection

Explore Oxford Nanopore’s ultra-rich multiomic workflows for comprehensive human variation analysis — including SNVs, structural variants, methylation, STRs, CNVs, and phasing. In this masterclass, you will learn: How to obtain multiomic data from a single sequencing run The sample-t