Cancer research
Getting started guides
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A guide to Adaptive Sampling: targeted sequencing reimagined from Oxford Nanopore
This guide introduces Adaptive Sampling, a unique on-device, real-time targeted sequencing method, providing an enhanced whole-genome view.
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A guide to transcriptomics with Oxford Nanopore
This guide introduces cDNA and direct RNA Oxford Nanopore sequencing, for ultra-rich transcriptomic data without compromise.
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A guide to targeted sequencing with Oxford Nanopore
This guide provides an introduction to performing targeted nanopore sequencing.
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A guide to human genomics with Oxford Nanopore
This guide introduces how to sequence human genomes with Oxford Nanopore, from the construction of new, highly complete reference assemblies to the comprehensive identification of variants.
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A guide to investigating methylation in the human genome
This guide provides an introduction to the direct sequencing of DNA methylation in human genomes.
Most viewed
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Rapid, multiomic tumour methylation profiling using Oxford Nanopore sequencing
In this application note, discover the tumour methylation profiling solutions, three flexible workflows for comprehensive tumour profiling in a single workflow.
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Tumour methylation profiling
In this flyer, discover our tumour methylation solutions to comprehensively profile solid tumours using one of our research protocols.
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Comprehensive genomic and epigenomic profiling with the Oxford Nanopore Hereditary Cancer Panel
In this application note, we present the design and performance of the Oxford Nanopore Hereditary Cancer Panel targeting 258 key genes implicated in cancer predisposition.
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Hereditary Cancer Panel: targeted sequencing via adaptive sampling
In this flyer, discover how to utilise the Oxford Nanopore Hereditary Cancer Panel to investigate 258 key genes associated with hereditary cancer risk.
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Go with the gold standard in methylation sequencing
In this flyer, find out how Oxford Nanopore provides gold-standard methylation sequencing and comprehensive variant calling in a single run — without chemical conversion.
Workflow overviews
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Comprehensive characterisation of cancer predisposition genes using the Hereditary Cancer Panel
Discover the Hereditary Cancer Panel workflow and streamline your precision oncology research.
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Comprehensive human genomic variant and methylation analysis with long Oxford Nanopore reads
This end-to-end workflow provides a scalable method to identify previously hidden and potentially pathogenic variants.
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Sequencing full-length transcripts for isoform-level expression analysis
This end-to-end workflow provides a flexible method to sequence full-length transcripts for isoform-level expression analysis.
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Characterising genomic and epigenomic variation between tumour-normal research samples using long nanopore sequencing reads
This end-to-end workflow overview provides a simple solution for detecting a wide range of tumour-specific variation in a single sequencing assay.
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Obtaining full-length isoforms from single cells with Oxford Nanopore sequencing
This end-to-end workflow provides a simple solution for single-cell transcriptome analysis from 10x Genomics cDNA with library preparation in approximately three hours.
Featured resources
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Adaptive Sampling enables rapid and complete profiling of pediatric cancers | LC26
Timely and comprehensive molecular classification is essential for therapeutic decision-making in pediatric oncology, yet current diagnostic workflows rely on multi-step, time- and resource-intensive testing. We present a standardized Oxford Nanopore Technologies whole-genome sequencing approach usi
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Building a multiomic homologous recombination deficiency clinical test using Adaptive Sampling | LC26
Homologous recombination deficiency (HRD) affects breast, ovarian, pancreas and prostate cancers. Patients with HRD tumours can respond to poly ADP-ribose polymerase (PARP) inhibitors and platinum-based therapies. HRD results in a variety of single base, insertion and deletion, and large structural
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New approaches for human and clinical research
Explore the advantages of Oxford Nanopore sequencing to detect genomic and epigenomic variants in human and clinical research.
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Accelerating cancer research through comprehensive genomic analysis
Unlock previously hidden variation with nanopore sequencing and characterise cancer at unprecedented resolution.
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How do I perform real-time targeted Oxford Nanopore sequencing?
What if targeted sequencing took place during sequencing itself, without the need for special library prep, PCR, or probes? In this demo, discover Adaptive Sampling: a unique, real-time targeted enrichment/depletion method that achieves just that.
Protocols
Analysis workflows
wf-somatic-variation
This workflow calls variants from the alignment files of a paired tumor/normal sample.
Latest research
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Integration-associated paraspinal neoplasm after AAV gene therapy
Authors: Josh N Vo, Yi-Mi Wu, Amer Heider, Xuhong Cao, Rui Wang, Tiffany Pham, Guo Ci Teo, Suresh N Magge, Hemant Parmar, Rajen Mody, Dan R Robinson, Arul M Chinnaiyan
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Accelerated and comprehensive paediatric cancer profiling using whole-genome sequencing with Adaptive Sampling
Authors: Nicholas Geoffrion, Charlene Lawruk-Desjardins, Sylvie Langlois, Marjorie Aleman Alvarado, Niklas Dreyer, Véronique Lisi, Mélanie Sagniez, Anthony Claude Carrier, Chantal Richer, Alex Richard St-Hilaire, Pascal Tremblay-Dauphinais, Alain R. Bataille, Thomas Sontag, Séverine Landais, et al.
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Adaptive sampling explained: the future of flexible target enrichment
Join us for a deep dive into adaptive sampling, a unique software-based target enrichment method from Oxford Nanopore Technologies.
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ROBIN - revolutionising brain tumour classification with real-time Oxford Nanopore sequencing and adaptive sampling
Learn how real-time Oxford Nanopore sequencing results enables rapid methylation classification of tumours.
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Richer insights with adaptive sampling: targeted panels without probes for cancer predisposition, tumor profiling and beyond
Learn about Oxford Nanopore's off-the-shelf solutions for creating simple, rapid custom panels providing data-rich scalable insights into cancer biology.
