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Chromatin conformation

A complete, end-to-end workflow for chromosome conformation capture

Chromatin conformation capture (3C) techniques reveal genomic interactions in three dimensions. This can provide key information on the effect of chromatin structure on transcriptional regulation; the data can also be utilised to orient contigs, producing highly contiguous scaffolded assemblies.

The traditionally used short-read 3C methodology limits the number of contacts available to analyse per read. Combining chromatin conformation capture with long Oxford Nanopore reads, Pore-C provides long-range contact information, shedding light on higher-order structure. The technique is PCR free, allowing the characterisation of base modifications in the same dataset.

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