New insights into large genomes white paper

Overview

Since the entire genome of the first organism was sequenced in 1995, thousands of completed genomes covering archaea, bacteria, and eukarya have been generated. However, the term ‘completed genome’ is overused because most sequenced genomes contain numerous gaps. These gaps correspond to repetitive regions and structural variants that are too large to be resolved by the legacy short-read sequencing technologies often used to generate the genomes. This white paper outlines how researchers are now utilising nanopore sequencing to address this challenge by spanning complex genomic regions in single reads, delivering more accurate large genomes for a wide variety of applications.

In this white paper, you will:

• Learn the importance of complete genome assemblies and its recent developments
• Discover the limitations of legacy sequencing technologies
• Find out how nanopore sequencing overcomes these limitations
• Read real-world case studies of how researchers are utilising nanopore sequencing to deliver new insights