Comprehensive genomic and epigenomic profiling with the Oxford Nanopore Hereditary Cancer Panel
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Overview
The Oxford Nanopore Hereditary Cancer Panel (HCP) targets 258 predisposition genes using adaptive sampling of long nanopore reads, enabling comprehensive detection of single nucleotide variants, insertions/deletions, structural variants, pseudogenes, and repetitive regions, alongside low-pass whole-genome coverage to enable copy number variant detection in a flexible workflow. The panel also enables direct methylation profiling without additional sample preparation.
This application note highlights how the HCP provides a scalable, accessible, and cost-effective solution for comprehensive analysis of hereditary cancer genes, with the potential to advance precision oncology.
In this application note, you will:
- Learn the importance of comprehensive detection of variants, many of which are missed by short-read methods
- Discover how adaptive sampling has the potential to provide a transformative alternative to traditional targeted sequencing approaches
- View our benchmarking data generated using the HCP
