Main menu

A guide to investigating methylation in the human genome


Getting started guide: methylation in the human genome — 2 pages

Overview

Epigenetics is the study of chemical modifications that can alter phenotype without altering nucleotide sequence. The most well-characterised and widely studied modification in mammalian including human genomes is 5mC DNA methylation — the addition of a methyl group to a cytosine nucleotide.

In this getting started guide, discover how to sequence epigenetic modifications directly from native DNA molecules without PCR or additional library preparation steps to reveal how methylation impacts phenotype, including its role in regulating gene expression.

In this getting started guide, you will:

  • Find out how direct DNA Oxford Nanopore sequencing enhances the analysis of epigenetic modifications
  • Discover the benefits of Oxford Nanopore sequencing
  • Identify the appropriate Oxford Nanopore sequencing kit for your experiment
  • For any questions, see the FAQs for this technique
  • Read real-world case studies of how researchers are utilising Oxford Nanopore sequencing to understand aberrant methylation in gene promoters and its association with disease

Download

Getting started

Buy a MinION starter pack Nanopore store Sequencing service providers Channel partners

Quick links

Intellectual property Cookie policy Corporate reporting Privacy policy Terms & conditions Accessibility

About Oxford Nanopore

Contact us News Media resources & contacts Investor centre Careers BSI 27001 accreditationBSI 90001 accreditationBSI mark of trust
English flag