Understanding bacterial DNA methylation and analysis methods
)
- Published on: June 10 2026
How do you analyse DNA methylation from nanopore sequencing data?
Oxford Nanopore sequencing technology offers direct detection of DNA methylation by interpreting changes in the electrical signal as native DNA strands pass through the pore. This eliminates the need for chemical conversion or amplification, enabling a streamlined workflow for modification analysis.
In this webinar, we demonstrate an end-to-end bacterial methylation workflow, featuring:
How the ATCC Genome Portal (AGP) provides high-quality assemblies, annotations, and methylation data
Best practices for assembly and polishing to enhance modification detection
Strategies to progress from assembly outputs and BED files to comparative motif analysis, using Helicobacter pylori datasets as an example
Guidance on when to use v6 HAC (High Accuracy) or SUP (Super Accuracy) models in bacterial analysis workflows
Jonathan Jacobs - ATCC, Art Rand and Katherine Lawrence - Oxford Nanopore Technologies
