Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines

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Using direct RNA Oxford Nanopore sequencing, researchers uncovered a novel mechanism enhancing mRNA vaccine performance: re-adenylation by TENT5A. This enzyme extends mRNA poly-A tails to boost mRNA stability and antigen production. This study showcases how nanopore sequencing enables real-time, single-molecule insights into mRNA metabolism — offering a strategy to improve future RNA-based therapeutics.

Authors: Paweł S. Krawczyk, Michał Mazur, Wiktoria Orzeł, Olga Gewartowska, Sebastian Jeleń, Wiktor Antczak, Karolina Kasztelan, Aleksandra Brouze, Katarzyna Matylla-Kulińska, Natalia Gumińska, Bartosz Tarkowski, Ewelina P. Owczarek, Kamila Affek, Paweł Turowski, Agnieszka Tudek, Małgorzata Sroka, Tomasz Śpiewla, Monika Kusio-Kobiałka, Aleksandra Wesołowska, Dominika Nowis, Jakub Golab, Joanna Kowalska, Jacek Jemielity, Andrzej Dziembowski, Seweryn Mroczek
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  • Published on: April 16 2025
  • Source: Nature