Comprehensive isoform characterisation and splicing signatures of AD-risk genes from long-read sequencing of tau mouse model
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In this study, we used two complementary targeted long-read sequencing approaches, Pacific Biosciences (PacBio) isoform sequencing (Iso-Seq) and Oxford Nanopore Technologies (ONT) nanopore cDNA sequencing, to profile the cortex of a mouse model of tau pathology (rTg4510) with ultra-deep sequencing of a panel of 20 genes robustly implicated in AD.