Haplotype-resolved DNA methylation at the APOE locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk

Genner et al. used Oxford Nanopore sequencing to map allele-specific methylation at the APOE locus — a gene central to Alzheimer’s disease risk — in postmortem brain research samples. They uncovered novel haplotype-resolved methylation signatures without the need for bisulfite conversion, far surpassing short-read methods. This study showcases the power of nanopore sequencing for high-resolution, phased epigenetic analysis in neurodegenerative disease research.

Sample type: human brain tissue

Kit: Ligation Sequencing Kit