Pharmacogenomics (PGx)
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Comprehensively characterise PGx variants in a single assay
PGx is the study of how genomics influences drug responses with the aim of identifying precise drug treatments for individuals. Genomic variants influence how drugs are absorbed, distributed, and metabolised (pharmacokinetics), as well as how they interact with biological pathways (pharmacodynamics).
Variants can also contribute to adverse drug reactions, such as hypersensitivity and allergic reactions, highlighting the need for personalised drug dosing based on genetics to improve treatment outcomes.
A major challenge of PGx is the complexity and diversity of variants, which cannot be characterised on one platform using legacy methods. Oxford Nanopore offers a complete PGx solution, enabling comprehensive analysis of all PGx variants in a single assay.
Featured content
Oxford Nanopore sequencing of PGx loci for calling variants
Highlighted publications that demonstrate how researchers are taking advantage of nanopore technology to study pharmacogenomics.
Real-time enrichment of a comprehensive PGx panel with Oxford Nanopore sequencing
Discover how Oxford Nanopore sequencing with adaptive sampling delivers accurate, comprehensive analysis of PGx targets from a single sample-to-star-allele workflow.
Recommended device for PGX sequencing
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GridION
The GridION is a compact benchtop device, designed to run and analyse up to five MinION Flow Cells. Run multiple experiments sequentially with the independently addressable flow cells and onboard compute — ideal for high-throughput sequencing of PGx genes.
