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Chromatin conformation

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Chromatin conformation document repository
31 个结果
Leveraging base modification information with Modkit | LC26Event video

Leveraging base modification information with Modkit | LC26

Nanopore sequencing reads from native DNA and RNA are inherently multiomic. However, using this data with confidence can be daunting. I will show how improvements in machine learning models have ...

Epitranscriptomic regulation of the developing human pancreas | LC26Event video

Epitranscriptomic regulation of the developing human pancreas | LC26

RNA modifications are crucial regulators of gene expression in human development. They have an established role in regulating pancreatic β-cell development and function, with dysregulation resulting in diabetes. Numerous ...

wf-pore-c

Workflow for analysing Pore-c data for chromatin conformation capture.

Verkko2: integrating proximity ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffoldPublication

Verkko2: integrating proximity ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffold

Publication: Verkko2: integrating proximity ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffold

Complex genetic variation in nearly complete human genomesPublication

Complex genetic variation in nearly complete human genomes

Publication: Complex genetic variation in nearly complete human genomes

Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumour-normal pair for somatic benchmarksPublication

Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumour-normal pair for somatic benchmarks

Publication: Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumour-normal pair for somatic benchmarks

Understanding the binding of multiple transcription factors by base-pair-resolution chromatin accessibilityResearch presentation

Understanding the binding of multiple transcription factors by base-pair-resolution chromatin accessibility

Abstract A fundamental challenge in studying cell function and disease is understanding how cis-regulatory regions control gene expression. Sequences of these regions specify the binding sites of multiple transcription ...

Translocation detection in cancer using low-pass pore-c sequencing

Translocation detection in cancer using low-pass pore-c sequencing | Welcome to Oxford Nanopore technologies. Our goal is to enable the analysis of any living thing, by any person, in ...

Complete sequencing of ape genomesPublication

Complete sequencing of ape genomes

Publication: Complete sequencing of ape genomes

A *ONECUT1* regulatory, non-coding region in pancreatic development and diabetesPublication

A *ONECUT1* regulatory, non-coding region in pancreatic development and diabetes

Publication: A *ONECUT1* regulatory, non-coding region in pancreatic development and diabetes

London Calling 2024 technology updateEvent video

London Calling 2024 technology update

Clive Brown is CTO of Oxford Nanopore, where he leads the innovation of breakthrough technologies and product development, that are designed to enable the analysis of anything, by anyone, anywhere ...

Genomic sequencing for characterizing tumor minimal residual disease versus early cancerResearch presentation

Genomic sequencing for characterizing tumor minimal residual disease versus early cancer

One of the most frequent translocations in leukemia involves the fusion of the KMT2A gene with numerous partner genes — this involves multiple breakpoint regions, spanning different exons. The KMT2A fusion ...

Chromatin accessibility sequencing from cell samples using SQK-LSK114

This protocol describes an end-to-end process to prepare and sequence gDNA for chromatin accessibility from cell samples, and to analyse the data using the information outlined in our ...

NCM 2023 Singapore: Direct detection of DNA modifications in human cancer genomesResearch presentation

NCM 2023 Singapore: Direct detection of DNA modifications in human cancer genomes

Epigenomic aberration is one of the hallmarks of cancer genomes. Global hypomethylation, aberrant hypermethylation at transcriptional regulatory regions (e.g. promoters, enhancers) and loss of imprinting have been widely revealed ...

Telomere-to-telomere nanopore-based genome assembly reveals genomic and epigenetic features of karyotype radiationPoster

Telomere-to-telomere nanopore-based genome assembly reveals genomic and epigenetic features of karyotype radiation

Telomere-to-telomere nanopore-based genome assembly reveals genomic and epigenetic features of karyotype radiation | Welcome to Oxford Nanopore technologies. Our goal is to enable the analysis of any living ...

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