Long-read genomes of 545 silkworms provide insights into domestication, breeding, and adaptation
About Xiaoling Tong
Xiaoling Tong, Ph.D., is a professor in the State Key Laboratory of Silkworm Genome Biology at Southwest University, China. She received her Ph.D. from Southwest University and completed her postdoctoral work in Antonia Monterio’s laboratory at Yale University. Currently, her laboratory focuses on the genetics and developmental biology of silkworms. This work utilises bioinformatics, molecular, and forward and reverse genetic approaches to address fundamental questions in developmental biology and conduct applied research on silkworm breeding.
The silkworm Bombyx mori is an important economic insect for producing silk, the 'queen of fabrics'. The currently available genomes limit a full understanding of its genetic diversity. Here, we assembled long-read genomes of 545 domestic and wild silkworms, and constructed a high-resolution pan-genome dataset. We provide examples to show the high efficiency of these genomes in deciphering the causal genes and variants associated with domestication, breeding, and ecological adaptation traits. This unprecedented, large-scale genomic resource allows for high-throughput screening of interesting traits for functional genomic research and breeding improvement of silkworms.