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Nanopore sequencing offers advantages in all areas of research. Our offering includes DNA sequencing, as well as RNA and gene expression analysis and future technology for analysing proteins.

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Nanopore Digest: Cell-free DNA sequencing and methylation calling for non-invasive cancer detection

28th July 2022

Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from nanopore sequencing

Here Katsman et al. show that cell-free DNA can be used to detect cell-type specific and cancer-specific methylation changes, as well as cancer-associated fragmentation signatures, using shallow Oxford Nanopore whole-genome sequencing (WGS) of liquid biopsies. Discussing the platform’s potential, they state that ‘the simplicity of native [nanopore] sequencing and the number of features that can be extracted from a single run, combined with the low cost and portability of [the] sequencer, make it an interesting proposition for clinical settings’.

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De novo assembly of human genome at single-cell levels

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Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections

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Community News

In the Nanopore Community, customers raise discussions to connect with others working on the same things, or give guidance to other users. Current discussions include:

  • RNA direct sequencing-Structure variant
  • Kit for metagenomic CSF sample
  • Short read lengths from plasmid sequencing
  • PCR Barcoding Amplicons

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Knowledge Exchange: Methylation detection with nanopore sequencing: Reduced-Representation Methylation Sequencing

This Knowledge Exchange, taking place on 16th August at 3 pm (BST), will introduce Reduced-Representation Methylation Sequencing (RRMS): a targeted methylation detection method utilising adaptive sampling for cost-effective, PCR-free enrichment during sequencing. With RRMS you can uncover changes in methylation patterns associated with changes in gene expression and diseases such as cancer, as well as call CNVs, without any additional sample prep.

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Cancer Research Symposium APAC

The mechanisms driving cancer are both diverse and complex. This symposium will bring together experts in cancer research, where they’ll cover how they are using nanopore sequencing to achieve the most comprehensive insight into cancer genomes.

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Webinar: Tumoroids from colon cancer, including WGS-strategy

In this webinar, Federica Di Maggio presented her analysis of tumoroids derived from study subjects with colorectal cancer. She discussed how nanopore tech identified pathogenic somatic mutations and its potential for precision medicine, in the future.

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Knowledge Exchange: Methylation detection with nanopore sequencing: an introduction to Remora

Catch up on this Knowledge Exchange to learn about recent updates in methylation and modified base detection from nanopore data, including the latest Remora algorithms. Learn why nanopore sequencing is now a new gold standard for methylation detection.

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