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Nanopore blog articles

Blog: Hot discussion topics from London Calling 2023 and looking forward to London Calling 2024

25th March 2024

What makes you happy? For me, it's chatting with varied scientists about their worlds, challenges and aspirations. Last year, at London Calling, I got to be a human watercooler by convening some ...

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Blog: Leaving the lab bench: on-farm genotyping in remote Australian cattle farms

25th March 2024

What is distinct about Australian cattle farms? Australian cattle farms are enormous. These large properties span thousands of square kilometres and some are larger even than small countries like I...

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Blog: Science unlocked: publication picks from Feb 2024

28th March 2024

Clinical microbiology Nanopore sequencing of infectious fluid is a promising supplement for gold-standard culture in real-world clinical scenario (Frontiers in Cellular and Infection Microbiology)

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Blog: Latest Direct RNA Sequencing Kit enables higher accuracy and output

28th March 2024

Native RNA sequencing Direct RNA sequencing is a unique capability of Oxford Nanopore technology. Thanks to the use of nanopores to directly sense information as strands of nucleic acids are fed th...

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Blog: Recognising the transformative research of the Nanopore Community on Rare Disease Day

25th March 2024

Revealing hidden genetic variants in rare disease with nanopore sequencing Danny Miller and Ahmad Tayoun's research is revealing hidden variants unresolved by traditional methods, highlighting the ...

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Blog: Congreso Futuro and the One Health expedition to the Atacama Desert

25th March 2024

In January 2024, a team of scientists led by Lara Urban and Matias Guitierrez, brought a splash of innovation to the driest and highest nonpolar desert on earth - the Atacama in Chile.

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Blog: The Pathologist: Sequencing-Based Metagenomics Could Improve Respiratory Testing

25th March 2024

It’s no wonder physicians take respiratory infections so seriously. They’re a leading cause of sepsis, a significant driver of antibiotic utilisation, and a potential trigger for new pandemics.

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Blog: The move from reference genomes to pangenomes for advancing genomic equity and personalised medicine

25th March 2024

Assembling reference genomes, and the Human Genome Sequencing Consortium (HGSC)  

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Blog: Multiomic single-cell cancer analysis — from mutation detection to understanding disease mechanisms

25th March 2024

Unlocking new biology Cancer is a highly heterogeneous disease with a wide distribution of mutations and clonal variation. To capture this data, single-cell RNA-sequencing (scRNA-seq) has become a ...

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Blog: Characterising alternative splicing in the human cortex with ultra-deep nanopore sequencing

25th March 2024

With the goal of ‘understanding both the causes and consequences of molecular variation in the human brain’, Jonathan and his group use a multiomic approach to study how the regulation of gene expre...

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Blog: Highlights from NCM Houston

25th March 2024

Future diagnostic potential for long-read sequencing as a single assay for imprinting disorders Cate Paschal (Seattle Children's Hospital & University of Washington, USA) introduced her plenar...

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Blog: Characterising Mycobacterium tuberculosis with nanopore technology

25th March 2024

Applying nanopore sequencing for analysis of drug-resistance Andrey described how he first heard about Oxford Nanopore Technologies when it was founded in 2005 and, from then on, was always curious...

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Blog: A new benchmark: discussing telomere-to-telomere assemblies with the founder of GrandOmics

25th March 2024

The foundations and vision of GrandOmics Could you share how GrandOmics was established and what the company's vision is?

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Blog: Revealing more to transform human health

25th March 2024

Out with the old. In with the future At the booth, we demonstrated both our wet and dry lab best practice workflows (check them out on our Resource Centre), and showcased our automated, sample-to-a...

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Blog: Oxford Nanopore meets Apple’s M3 silicon chip, hailing a new era of distributed genome sequencing

25th March 2024

The world is changing rapidly, and with it, our understanding of the molecular building blocks of life. Apple's recent announcement at their "Scary Fast" event introduced the power and speed of M3 s...

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Blog: Revealing hidden genetic variants in rare disease with nanopore sequencing

25th March 2024

Danny Miller — The 1000 Genomes Project Oxford Nanopore Sequencing Consortium: expanding our understanding of human genetic variation

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Blog: My research in 60 seconds — Improvements in direct RNA sequencing and its potential to transform clinical research

25th March 2024

Background to direct RNA sequencing As Martin highlights, the capacity to sequence native RNAs is one of the unique features of nanopore sequencing and a revolution for RNA biology. "Sequencing nat...

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Blog: Pioneering single-cell sequencing approaches to understand the 'dark matter' of our genome

25th March 2024

'During my postdoc research, I had already developed the first single-cell transcriptome sequencing technology in the world.' From pioneering postdoc to principal investigator in single-cell sequ...

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Blog: Honouring early nanopore pioneers and reflecting on our US heritage

25th March 2024

Sir Isaac Newton once remarked that scientific discovery was built on the shoulders of giants – and the journey of Oxford Nanopore Technologies is no exception. Multiple strands of inspiration, rese...

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Blog: Conserving a threatened North American walnut: a chromosome-scale reference genome for butternut (Julgans cinera)

25th March 2024

The conservation of native species is critical for maintaining biodiversity and healthy ecosystems in the face of increasing environmental threats. A team of students and faculty at the University o...

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Blog: My research in 60 seconds — Addressing the unmet needs in Alzheimer’s research through scalable nanopore sequencing

25th March 2024

Large-scale Alzheimer’s genetics research with nanopore technology – the Long-Read Sequencing project

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Blog: Nanopore sequencing for disease surveillance in low-resource settings — updates from London Calling 2023

19th March 2024

Nanopore sequencing for real-time genomic surveillance of Plasmodium falciparum William Hamilton Wellcome Sanger Institute, UK, and Cambridge University Department of Medicine, UK Dr Lucas Amenga-...

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Blog: Uncovering new genetic modifiers of monogenic Parkinson’s disease and parkinsonism-related disorders

25th March 2024

Nanopore technology allows single-molecule detection, which engages a whole new level of hypotheses on somatic variation.

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Blog: Liquid biopsies — multi-modal cell-free DNA assays using nanopore sequencing for potential cancer detection

27th March 2024

The use of liquid biopsies in cancer research involves taking blood samples to examine circulating tumour DNA (ctDNA) or cell-free DNA (cfDNA); they are particularly useful in paediatric cancers, si...

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Blog: Pushing the boundaries of rare disease research

25th March 2024

Solving genetically undiagnosed inherited neuropathy families: long-read sequencing to the rescue Marina Kennerson The ANZAC Research Institute, Australia

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Interview: Generating microbial insights from nanopore metagenomic data using an open-source, cloud-based metagenomics tool for researchers

12th May 2023

Sara Simmonds is a computational biologist at the Chan Zuckerberg Initiative (CZI), where she works closely with scientists, engineers, and the product team to develop open-source software for met...

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Blog: Understanding the genomes of weird and wonderful plants

25th March 2024

From identifying leaves to creating a plant sequencing lab

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Blog: Nanopore technology in liquid biopsy multi-modal analysis

25th March 2024

Filippo remembers that his real passion for science came during his internship for his Biotechnology degree. Being a bioinformatician had seemed like “black magic” when he was younger, but Filippo h...

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Interview: The frontlines of pathogen genomic surveillance with rapid nanopore sequencing

26th July 2022

                                     

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Interview: Optimisation and validation of a nanopore-based sequencing method for potential molecular testing of CNS tumours

11th July 2022

Mashiat Mimosa is a research-based MSc. student at University of Toronto’s Department of Laboratory Medicine and Pathobiology where her work focusses on cancer research, neuro-oncology, and genomi...

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Blog: What if you could take your lab in a backpack to explore life on Earth?

25th March 2024

Studying the diversity of life on our planet is no small task. Millions of species remain to be discovered or described in detail, while the loss of natural habitats and biodiversity continues to ac...

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Blog: Applying portable nanopore sequencing technology to the conservation of the critically endangered kākāpō

25th March 2024

"I really enjoy being out here...being on an island with kākāpō, even when you don't see them all the time...the feeling is really great."

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Blog: KeyGene — Next-level crop reference genomes using plant-trained basecallers and the latest sequencing chemistry

25th March 2024

In conjunction with this blog post, KeyGene has generated publically accessible assemblies and raw data for A. thaliana ecotype Columbia, and Tomato Heinz 1706. See here for full details Crop refer...

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Interview: Sequencing the poplar with PromethION

15th October 2021

with Héloïse Bastiaanse and Stephane Rombauts, members of the VIB-UGent Center for Plant Systems Biology Conducted and written by Jonathan Pugh “[On] PromethION we can actually sequence 10–12...

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Interview: Exploring complex disease in Asian populations with PromethION

6th August 2021

Health-related technologies exist in an ever-changing ecosystem, where continual developments drive new insights into human health and disease

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Blog: From kilobases to "whales": a short history of ultra-long reads and high-throughput genome sequencing

25th March 2024

The evolution of long reads picked up speed when the MinION Access Programme began in 2014. Right away from the Nanopore burn-in experiments, 10 kb reads became routine (10 kb because, as per recomm...

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Interview: The PromethION Experts at VIB

2nd July 2021

The PromethION from Oxford Nanopore Technologies has developed in a short space of time into a device with unrivalled output in the DNA and RNA sequencing space.

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Interview: Using PromethION for Cancer, Collaborations and more

25th June 2021

Despite its name, the Genome Science Centre at BC Cancer tackles a wide variety of sequencing challenges. In my discussion with Sequencing Group Leader Dr Richard Moore we touched on the variable op...

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Interview: PromethION 24 and human disease research

18th June 2021

with Eric Cabannes, Development Laboratory Manager at the Centre National de Recherche en Génomique Humaine (CNRGH) Conducted and written by Jonathan Pugh

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London Calling 2021: watch on demand!

6th May 2021

London Calling took place last week, but it’s not too late to register and catch-up on all the content on demand. The talks covered everything from methylation in degenerative disease research to ad...

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Blog: On the quest to assemble the giant lungfish genome

25th March 2024

Our closest relative Considered a “living fossil”, the Australian lungfish (Neoceratodus forsteri) was discovered just a little more than 150 years ago and was at first misclassified as an amphibia...

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Bringing Genomic COVID-19 Surveillance to the Developing World

11th March 2021

Kahlil Corazo is an entrepreneur and project manager from the Philippines who initiated and led Project Accessible Genomics, a low-cost genomic sequencing operation that aims to bring pathogen surve...

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Answered: 11 questions about presenting at London Calling 2021 (and why we’d love you to take part)

17th February 2021

Due to current COVID-19 restrictions and following on from the success of last year’s virtual London Calling conference, the upcoming London Calling 2021 is also going ahead online. Kicking off o...

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Structural variation & cancer: top 7 things to read right now

20th November 2020

Somatic mutations are the driving force behind cancer development, and structural variations (SVs) are more and more being recognised as an important class of these mutations. The detection of SVs i...

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Interview: Nanopore sequencing: the mobile methylome

17th November 2020

Adam Ewing leads the Translational Bioinformatics Group at the Mater Research Institute - University of Queensland in Australia, where he works to develop methods and software for analysing high ...

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Structural variation in human genomics: 6 things to read right now

3rd November 2020

The significance of structural variation in human genomics is becoming increasingly established in many fields, from cancer to neurology and the mechanisms of rare disease. With research moving at a...

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Epigenetics, Cas9-mediated enrichment and novel insights in transcriptome variation: catch up on talks from ASHG 2020

30th October 2020

This week we heard from Ariel Gershman, Shruti Iyer and Tuuli Lappalainen on their latest research addressing some of the key challenges in human genomics using nanopore technology. The talks are no...

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Your Oxford Nanopore guide to ASHG 2020 online

26th October 2020

ASHG 2020 has moved online this year but there’s still plenty going on and lots of ways you can find out about how human genomics researchers are overcoming some of the big challenges in the field...

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Blog: cuteSV - a powerful tool to uncover the full spectrum of genomic structural variants

19th October 2020

In this blog, Tao Jiang describes his work on the development of the structural variant (SV) caller cuteSV.

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Blog: Copy number variation analysis from plasma: is it feasible using nanopore sequencing?

29th September 2020

In this blog, Filippo Martignano shares his research into copy number variation (CNV) analysis in cancer, from cell-free DNA samples, using shallow whole-genome sequencing.

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Blog: Resolving structural variants causing antithrombin deficiency

14th September 2020

In this blog, Alba Sanchis-Juan, Javier Corral, and Belén de la Morena-Barrio describe their research into the genetic basis of thrombophilia, and how nanopore long sequencing reads were needed to r...

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Blog: Revealing the impact of structural variants on cancer susceptibility

2nd September 2020

In this blog, Katherine Dixon shares her team’s work on identifying structural variants in cancer genomes, and she explains why identifying them accurately is so important. Katherine DixonI am a...

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Blog: Ruminating on the rumen microbiome

9th June 2020

In this blog, Beatriz Delgado Corrales, Óscar González Recio, and Mónica Gutiérrez Rivas describe their work on classifying rumen microbiomes, comparing long-read and short-read sequencing platforms...

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Interview: Nanopore sequencing: the missing puzzle piece in molecular identification

11th May 2020

Ahmed Abd El Wahed is a scientist at the Institute of Animal Hygiene, University of Leipzig, and established a mobile suitcase laboratory for the rapid detection of viruses, bacteria and parasites...

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Blog: PuntSeq - Portable nanopore sequencing of freshwater metagenomes

17th April 2020

In this blog, Lara Urban discusses the importance of freshwater microbial monitoring, and the founding of PuntSeq – a citizen science effort centred around using nanopore sequencing technology to ga...

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Blog: Metagenomic sequencing: which assembly method is best?

7th April 2020

In this blog, Adriel Latorre-Perez shares his work on comparing methods for assembling metagenomes from nanopore sequencing data, and he provides recommendations on the best tools to use for the job...

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Blog: Long reads reveal small-scale structural variations in an allo-tetraploid crop plant

25th February 2020

Harmeet Singh Chawla, from Justus Liebig University Giessen, discusses how he developed a pipeline using long nanopore reads to investigate genomic structural variation in the major crop Canola. ...

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Interview: Nanopore sequencing in plants: from greenhouse to genome

10th February 2020

Date: Tuesday 18th February Time: 3pm UK time Speaker: Maximilian Schmidt, RWTH Aachen University Maximillian Schmidt is currently completing a PhD at RWTH Aachen University where he is using ...

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Blog: Plant genome hybrid assembly with MaSuRCA

15th January 2020

In the first of a new series of blogs from members of the Nanopore Community, Aleksey Zimin from Johns Hopkins University discusses his software MaSuRCA, which uses long nanopore reads to enhance th...

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Nanopore Community Meeting 2019: Day 2

6th December 2019

The second day of the Nanopore Community Meeting 2019 in New York was no less packed than the first, with tonnes of great talks from a huge range of speakers. Here are just a few of the highlights, ...

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Nanopore Community Meeting 2019: Day 1

5th December 2019

The first day of Nanopore Community Meeting 2019 in New York has been a day packed full of talks. Videos and recordings of all the talks will be online soon, but for now, here are a few highlights. ...

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Interview: Improving the polar bear transcriptome using long-read sequencing and Cas9 depletion

29th October 2019

Date: Thursday 7th October Time: 4pm GMT Speaker: Ashley L. Byrne, University of California, Santa Cruz

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Interview: Old is new: maximizing read lengths and yield for genome assembly

22nd October 2019

Date: Thursday 24th October Time: 4pm UK time Speaker: John Tyson, University of British Columbia

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ASHG 2019: An Oxford Nanopore Guide

15th October 2019

Are you in Houston this week for the biggest human genomics conference of the year? Our team would love to hear what you’re working on! You’ll find us at booth 1127 with technology and application ...

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Nanopore Tech Tour: a round up from Shanghai

27th September 2019

Yesterday the Nanopore Tech Tour landed in Shanghai for another fantastic day of talks, live sequencing demos, tutorials and flow cell loading clinics. Read on for summaries of the talks. ​

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Nanopore Tech Tour: a round up from Beijing

26th September 2019

This week, we're hosting the first Nanopore Technology Tour in China. On September 23rd we kicked off in Beijing with an excellent line-up of speakers from the Nanopore Community and a packed age...

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Interview: Long-read sequencing technologies reveal mutations lurking in the “camouflaged” genome

24th September 2019

Date: Tuesday 8th October Time: 4pm BST/11am EDT Speaker: Mark Ebbert, Mayo Clinic

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11 questions about NCM 2019 answered

20th September 2019

With only 11 weeks to go until we meet in New York City, here are 11 things you may be wondering about the Nanopore Community Meeting (and 11 reasons we’d love to see you there):

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A summer* of nanopore – are you up to date?

17th September 2019

As we gear up for what's set to be a busy rest of 2019, with a China Nanopore Tech Tour just around the corner and the New York Community Meeting hot on its heels, we’re taking a moment to reflec...

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Interview: Single-cell nanopore sequencing allows high-throughput multiomic analyses of cellular diversity in disease

28th August 2019

Date: Thursday 29th August 2019 Time: 4pm BST/11am EDT/8am PDT/1am Sydney Speaker: Ghamdan Al-Eryani, Garvan Institute of Medical Research

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7 breakthroughs in RNA research from the Nanopore Community

1st August 2019

On RNA Day 2019 we're taking the time to celebrate some ground-breaking work from the Nanopore Community, across the field of transcriptomics. These examples utilise both methods we offer for long-r...

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Interview: Digging up the dirt using rapid genomic discovery with nanopore sequencing

20th June 2019

Technology Networks webinar Date: Thursday 27th June 2019 Time: 11am EDT/4pm BST/7am Alaska Speaker: Devin Drown, Assistant Professor at University Alaska Fairbanks

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London Calling 2019 day 3: populations-scale SV with PromethION, forensics, direct RNA, more

24th May 2019

The final day of London Calling saw some impressive science in compact formats - read the plenary write ups below, or head over to the Nanopore Community to see the full live blog! Min Sung Park: ...

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London Calling 2019, Day 2: cancer research, completing human chromosomes, epigenetic signatures of viruses, more

23rd May 2019

The second day of talks at London Calling saw some phenomenal science - from completing the human genome to using cell-free DNA to investigate residual disease in cancer. Get the run-down of all th...

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London Calling 2019 day 1: RNA base modification, haematology, mRNA in the human brain, more

22nd May 2019

It's been a fantastic and packed out first day in Old Billingsgate for London Calling! The summaries of the key plenary talks can be found below recounting all the action; keep track of everything g...

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London Calling: Live first-time sequencing of the Fever Tree - the plant that some say has saved millions of lives from malaria

22nd May 2019

Today, the annual London Calling conference starts. 600 attendees from all over the world have converged on Old Billingsgate to discuss all things nanopore, to hear 87 speakers and read 81 posters ...

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ECCMID: An Oxford Nanopore guide to ECCMID

11th April 2019

If you're in Amsterdam this weekend for ECCMID 2019, please do come and say hello at booth 1.23. PromethION, GridION, MinION and Flongle will be on display and we're bringing a range of technolog...

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Interview: The SG-NEx project: nanopore long-read RNA-sequencing of human cancer cell lines

31st January 2019

Webinar date: Thursday 28th February (pre-recorded on 21st February) Time: 12pm EST/5pm GMT/9am PST Speaker: Jonathan Göke, Genome Institute of Singapore (A*STAR)

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Interview: Transcriptome of an agricultural pest delineated by Oxford Nanopore RNA-Seq

25th January 2019

Webinar date: Thursday 14th February Time: 12pm EST/5pm GMT/9am PST Speaker: Anthony Bayega, McGill University, Canada Anthony Bayega is currently completing a PhD at McGill University in Canada,...

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Nanopore Community Meeting 2018 - Day 2 writeup

29th November 2018

Plenary: Michael Schatz

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Nanopore Community Meeting 2018 - Day 1 writeup

28th November 2018

After the conclusion of the action from day one of the Nanopore Community Meeting 2018 in San Francisco, here's a detailed roundup of the talks! For more information on the talk by Oxford Nanopor...

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Interview: Genome Insights enabling crop innovation using PromethION

13th November 2018

Date: Tuesday 20th November Time: 3pm GMT Speaker: Alexander Wittenberg, KeyGene

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Interview: Maize genome complexity traversed with Oxford Nanopore Technology

5th November 2018

Frontline Genomics Webinar Date: Thursday 8th November Time: 10am PST/1pm EST/6pm GMT Speaker: Todd P. Michael, PhD, Professor and Director of Informatics, JCVI

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Nanopore Community Meeting (28-29 Nov) will feature talks from CTO Clive G. Brown, 50 users of nanopore sequencing. Get your ticket now!

2nd November 2018

The 4th Nanopore Community meeting will be held 28-29 November in San Francisco, with a workshop on 27th November. Browse the agenda and book your place. What to expect Nanopore technology update...

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Oxford Nanopore evening seminar at American Society of Human Genetics (ASHG): brief summary

22nd October 2018

At this year's ASHG, nanopore data was presented in a total of 26 talks/posters, read this ASHG guide for more information. In the evening, Oxford Nanopore hosted a seminar and gave a technical upd...

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ASHG: An Oxford Nanopore guide to ASHG

16th October 2018

If you are in San Diego at this week's ASHG meeting, please come and visit us at booth 435. We will have PromethION, GridION and MinION on display and a range of technology and application experts ...

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Interview: Human genome sequencing on PromethION: characterisation of structural variants and repetitive regions

9th October 2018

Frontline Genomics Webinar Date: Thursday 11th October Time: 4pm BST/5pm CEST Speakers: Arne De Roeck & Wouter De Coster

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London Calling: Day 2 (afternoon) writeups

27th May 2018

A blog summarising presentations from the London Calling Conference, May 2018. Thanks for visiting our writeup page. We'll continue to update it over the coming days so please check back soon! Pl...

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London Calling: Day 2 (morning) writeups

25th May 2018

Updates from the morning of the second day at London Calling

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London Calling: Day 1 (afternoon) writeups

24th May 2018

A blog summarising presentations from the London Calling Conference, May 2018. Thanks for visiting our London Calling writeup page. We'll continue to update it over the coming days so please check ...

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London Calling: Day 1 (morning) writeups

24th May 2018

The annual London Calling conference kicked off today at Old Billingsgate in the City of London. This blog contains writeups of many of the talks, or you can also follow the action at Twitter on #n...

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2017 was busy, and here's why. Happy New Year 2018

8th January 2018

Welcome back to 2018!

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Community meeting videos now available

14th December 2017

The Nanopore Community Meeting concluded on 1st December, gathering 300 people in New York. Videos of the sessions are now being released online, you can find them here. Writeups of Day 1 and Day ...

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Nanopore Community Meeting - Day 2 writeup

11th December 2017

Gordon Sanghera opened Day 2 to Blondie, of course, and by announcing that two service providers have now completed certification and are offering nanopore sequencing as a service using GridION. re...

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Nanopore Community Meeting 2017: Day 1 write-up

30th November 2017

Day 1 of the Nanopore Community Meeting is done, and if you were not there in person, you may have been following #nanoporeconf on twitter. Videos of the sessions will be released soon. In the mean...

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New applications posters released for Nanopore Community Meeting

28th November 2017

Later this week, scientists will be gathering in New York to discuss their latest research using Nanopore DNA or RNA sequencing. You can see the agenda for the Nanopore Community Meeting here. If...

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Oxford Nanopore at ASHG 2017

18th October 2017

Since ASHG last year, the MinION has been used to sequence human genomes (and also large plant genomes), the higher-throughput GridION and PromethION have emerged, new direct RNA and cDNA sequencing...

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London Calling 2017: Day 1 updates

5th May 2017

It's been a long day at Old Billingsgate in London, where 400 people gathered from 25 countries to share their experiences of nanopore sequencing. Other talk summaries, in brief:

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In Brief: Oxford Nanopore updates at the Nanopore Community meeting in New York

2nd December 2016

It has been a busy week in New York. Presentations will be released soon, but in the meantime you can review updates by following #nanoporeconf on social media or the updates here on the news page. ...

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Update from Day 2 of the Nanopore Community Meeting in New York: Cas9 enrichment, long reads in transcriptomics, fungal pathogen outbreak surveillance, more

2nd December 2016

The 200 attendees returned after a busy Day 1 to a day of plenaries, breakouts and discussions.

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Update from Day 1 of the Nanopore Community Meeting in New York: infectious disease, first human genomes on a MinION, Clive Brown plenary, more

2nd December 2016

Thursday was a busy day at the Nanopore Community meeting in New York. 200 attendees travelled to the Metropolitan Pavilion to listen to plenaries, take part in breakout sessions and view the techno...

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London Calling conf concludes - watch the talks and review the announcements

27th May 2016

The London Calling conference in London has now concluded. More than 250 scientists with an interest in nanopore sequencing gathered to watch plenary talks, review posters, surf the Live Lounge wher...

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Oxford Nanopore to present DNA 'strand sequencing' at AGBT conference; commercialise directly in 2012

1st February 2012

Oxford Nanopore Technologies Ltd. announces that Clive G Brown, Chief Technology Officer, will present at the Advances in Genome Biology and Technology (AGBT) conference in Marco Island, Florida, on...

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